Updated on June 25th, 2022

CBD for Nausea

CBD for nausea is now appreciated as a remedy by many, thanks to researchers and scientists in the field of cannabis. Nausea is defined as a feeling of sickness that will often lead to vomiting. The uneasiness of the stomach and involuntary expulsion of stomach contents are two common symptoms that torment the body.

70% – 80% of all pregnant women experience nausea according to a study published in PubMed in June 2013.

Because nausea is a widespread symptom and side effect, there are many causes. Sensitivity to motion, specific foods, medications or medical conditions can all trigger this discomfort.

One of the most common nausea triggers is heartburn. More than 40% of Americans suffer from a “burning throat” pain-induced nausea at least once a month.

What Causes Nausea?

Nausea can be both short and long-term depending on the source. Possible causes include

  • Poisoning (food, carbon monoxide, toxins, alcohol)
  • Ear disorders and infections
  • Medication or diet (chemotherapy, anesthesia/post-operative vomiting, antibiotics)
  • Seasickness and vertigo
  • Viral infections (stomach flu)
  • Pain due to an underlying illness
  • Migraines and headaches
  • Early stages of pregnancy
  • Depression, anxiety, emotional stress, and eating disorders
  • Ulcers

Conditions that could Cause Nausea:

Although some cases can be easily treated through hydration, medication, and diet, there are many serious ailments where nausea is a symptom. These conditions include:

  • Heart attacks
  • Brain tumors
  • Pancreatitis
  • Certain forms of cancer
  • Head injuries and concussions
  • Liver failure

In 2004, a study published on PubMed shows that of 243 cancer patients, about 42% – 52% encountered nausea related to their chemotherapy treatment.

Cannabidiol Background

One of the many phytocannabinoids responsible for the medicinal benefits of cannabis; CBD is most commonly found in the hemp plant varieties. As legalization continues to thrive, CBD is also becoming more prevalent in medicinal cultivars such as ACDC and Charlottes Web.

Cannabidiol (CBD) will often be combined with tetrahydrocannabinol (THC) medicine to alleviate the negative impairing effects and support additional advantages known as “the entourage effect”. D8-THC might be a solution if you need something stronger than CBD but don’t like the mental impairment effects of delta-9-THC.

CBD for Effective Nausea Relief

Cannabidiol and its precursor acid form CBD-A (through decarboxylation, the acid will transform to CBD from heat over time). Both are powerful in managing acute and anticipatory nausea – which is often caused by memory triggers. Further studies provide evidence into CBD’s ability to regulate anxiety, a surprising factor in some nausea cases.

Laboratory Studies

CBD is capable of interacting with multiple receptors and ion channels in the body. One is the 5-hydroxytryptamine (5-HT) receptors, where serotonin binds to the central and peripheral nervous system. In 2010, The British Journal of Pharmacology reviewed data from multiple animal studies and found CBD blocked serotonin production in the 5HT-1 receptor, which is thought to cause nausea. They gathered approximately ten additional species studies, including shrews, pigeons, cats, and dogs.

By blocking the release of 5-HT (serotonin) neurons in the forebrain region, CBD has decreased nausea when induced by medication. This analysis concludes that CBD is an excellent alternative for patients after recognizing the potentially dangerous side effects of pharmacological medications.

“Patients prefer marijuana over synthetic cannabinoids” – Dr. Rachna Patel.

Clinical Studies

Following repeated success in the recession of cancer in the 1960s, chemotherapy patients urged oncologists to explore a more natural remedy to their accompanying illness. In 1975 the New England Journal of Medicine published the first examination of cannabis for nausea. They performed a controlled, randomized, and double-blind experiment featuring oral THC and a placebo.

The study was based on anecdotal statements of smoked cannabis curbing nausea and vomiting during treatments. The placebo control group felt no change, while 14 of the 20 patients receiving THC encountered anti-emetic (anti-vomiting) effects.

Research efforts were first directed towards THC, but given the lack of cognitive impairing effects (THC is often impairing- especially to new patients), CBD oil for cancer treatment has recently received a lot of recognition. A 2011 clinical study on rats and mice, published by the Department of Psychology and Collaborative Neuroscience Program at the University of Guelph in Ontario, continued to advocate that CBD alone is efficient at treating both nausea and vomiting caused by medications.

CBD for Nausea during Pregnancy

Currently, the FDA has several approved medication options for pregnant women with morning sickness or experiencing nausea all day long, although not all are recognized to be very effective. Medical doctors often prescribe medications to women that are not FDA-approved for use while pregnant, such as ondansetron (Zofran), which can increase the risk of congenital heart disease and cleft palates in the fetus/infant.

CBD for morning sickness

Phytocannabinoids, once consumed, can distribute within the body and through the placental barrier. Affecting fetal blood, amniotic fluid, breast milk and fetal tissues. CBD, in particular, has been observed as being able to cross the placental barrier.

There is a lack of studies and information about the safety of CBD while pregnant. Cannabis is often found to slightly lower the birth weight of newborns. A remarkable study on cannabis use amongst pregnant women was conducted in 1994 by the School of Nursing from the University of Massachusetts by Dr. Melanie Dreher, PhD.

Unique Study on Jamaican Cannachildren

24 Jamaican children whose mothers smoked marijuana heavily during pregnancy were compared with 20 Jamaican children whose mothers didn’t use cannabis.

Over a period of five years, multiple tests were conducted and no neurobehavioral differences between the two groups were found. On the contrary, the cannabis babies showed overall better scores on alertness, stability, and self-regulation.

There are also studies that link cannabis use during pregnancy with slightly lower birth weight and premature birth of newborns. Many studies, however, have been influenced by factors such as tobacco and alcohol use, and it is difficult to find reliable evidence. There is a lack of studies about the safety of CBD while pregnant although there are many online anecdotal reports of mothers that used CBD during pregnancy.

According to Dr. Sanjay Gupta, 94% of medical cannabis studies are focused on what harm cannabis may do, whereas only 6% focus on the benefits – a bias that needs to be taken into consideration.

Hemp Use During or After Pregnancy in Ancient Civilisations

Dr. Christian Raetsch, Ph.D., studied this topic and published a book called “Marijuana Medicine, A world tour of the visionary and healing powers of cannabis”. He reports the following evidence of ancient hemp use during pregnancy and childbirth:

  • Tibet

    Cannabis was given for:

    • Childbirth support
    • Post delivery support
    • Prevention of infections
    • Postpartum depression
  • Assyria

    Cannabis roots were given for:

    • Difficult births
  • Old Germany

    Heated hemp mixture was rubbed on mothers breasts for:

    • Breastfeeding production boost
  • Southern Africa

    Cannabis was and still is used for:

    • Labor pain mitigation
    • Pregnancy support
  • United States

    From mid-1800’s through the 1950’s Cannabis was used in prescribed medication for:

    • Weak labor contractions
    • Difficult labor
    • Vomiting during pregnancy

Dr. Ethan Russo, MD

Hyperemesis Gravidarum – Excessive Vomiting during Pregnancy

Dr. Ethan Russo, MD., has been reported saying: “Excessive vomiting, hyperemesis gravidarum, is a very dangerous condition, potentially life-threatening to mother and fetus, often requiring extensive hospitalization with the administration of many ineffective and possibly toxic medications. It is well established historically that small doses of cannabis can be extremely effective in allaying nausea and vomiting in this context.”

Dr. Russo also studied and documented the ancient usage of cannabis-related to pregnancy.

  • United States

    Additionally, in the mid-1800’s Cannabis was used in prescribed medication for:

    • Labor aid without anesthesia
  • Egypt (3000 BCE)

    Cannabis was given for:

    • Labor aid
  • China

    During ancient and contemporary times cannabis has been given for:

    • Stimulating breast milk production
    • Delivery aid

CBD Oil Dosage for Nausea

As with any new medication, it is always beneficial to start low and go slow. Although CBD is safe and impossible to overdose from, the lowest dose will perpetually be the most therapeutic.

CBD oil sublingual doses beneath the tongue are the most powerful method delivering the quickest absorption possible. Dosages as low as 30mg may be successful but each endocannabinoid system is unique.

Take CBD for nausea on an as-needed basis when you feel sick. It is best to take it three times a day as the cannabidiol effects diminish after 6 – 8 hours. For example in the morning 30 mg, in the afternoon 30 mg and in the evening 30mg

A chemotherapy patient or individual experiencing severe nausea may start at 50mg up to 150mg or more. Increase your dose every four days if you believe you are experiencing fewer effects (be sure to record doses and effects). The body will naturally get used to the CBD and its results may take a couple of days.

Although researchers are still unable to understand the neural mechanisms of the emetic reflex, an incredible amount of scientific evidence demonstrates a remedial administration of CBD to the endocannabinoid system is sufficient to many as an anti-emetic. CBD has shown to be an astonishing medicine and a natural solution to nausea.

  • What Daily Dosage Works Best for You?

    Please share your thoughts in the comment section below this article on what dosage worked best for your treatment. This way other people will benefit from your experience. Thanks!

Success Stories of Nausea Patients

We have carefully collected CBD testimonials for this particular condition to serve as proof and inspiration to others. Do not hesitate to record your own experience and share it with us so we can add it to this list and help thousands of other patients.

Overview of Scientific Studies and Reports

If you are interested in the medical proof and not scared of reading through some professional medical jargon, check out the studies below.

Best CBD for Nausea


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